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Almost ready for phase 1: JHU083 (or JHU-083) a selective glutamine metabolism blocker
"The drug, JHU083, is a type of molecule called a prodrug that cells inside the body convert into an active drug. Specifically, JHU083 can only be turned into its active, glutamine-blocking form inside the tumor, preventing it from causing harmful side effects elsewhere in the body. " We all know that
"The drug, JHU083, is a type of molecule called a prodrug that cells inside the body convert into an active drug. Specifically, JHU083 can only be turned into its active, glutamine-blocking form inside the tumor, preventing it from causing harmful side effects elsewhere in the body. " We all know that
Maxone73
in
Advanced Prostate Cancer
9 hours ago
Newly diagnosed. Looking for advice
Good morning. I've sadly recently been diagnosed with ulcerative colitis. I was suffering 5 years ago with calprotectin score 450 and had a urgent colonoscopy that found polyps and piles which were removed biopsied/ banded. Continued to have on off blood in stools for a few years each time I was blaming
Good morning. I've sadly recently been diagnosed with ulcerative colitis. I was suffering 5 years ago with calprotectin score 450 and had a urgent colonoscopy that found polyps and piles which were removed biopsied/ banded. Continued to have on off blood in stools for a few years each time I was blaming
Raerae2781
in
Crohn's and Colitis Support
1 day ago
Please Help Me.
Hello all! I'm a 29 year old guy from the UK. I've had diarrearh for nearly 6 weeks. I have severe bloating. I was admitted to Hospital last week, they've asked me to do a Bowel cancer sample test (which I've done) During the blood tests they've found my Liver Enzymes are elevated. They've ordered
Hello all! I'm a 29 year old guy from the UK. I've had diarrearh for nearly 6 weeks. I have severe bloating. I was admitted to Hospital last week, they've asked me to do a Bowel cancer sample test (which I've done) During the blood tests they've found my Liver Enzymes are elevated. They've ordered
Lmm4
in
British Liver Trust
1 day ago
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Bloating for 2 months
Hi, does anyone suffer with bloating but all the time? For the last couple of months my stomach has felt bloated most days and more recently I have had a gurgling stomach, mucus in my poo, lower back pain, urgency and acid reflux. I am currently having bloods, stool samples etc to rule out other things
Hi, does anyone suffer with bloating but all the time? For the last couple of months my stomach has felt bloated most days and more recently I have had a gurgling stomach, mucus in my poo, lower back pain, urgency and acid reflux. I am currently having bloods, stool samples etc to rule out other things
Starshine83
in
IBS Network
2 days ago
Functional Gerd/Heartburn
Good day everyone, has anyone ever researched this topic ? I was diagnosed with AIG few months back, started EOD injections and recently developed what feels like heartburn, which I have never had before. The pain is usually in bottom chest area and is accompanied with flatulence and burping. I read
Good day everyone, has anyone ever researched this topic ? I was diagnosed with AIG few months back, started EOD injections and recently developed what feels like heartburn, which I have never had before. The pain is usually in bottom chest area and is accompanied with flatulence and burping. I read
Canadian77
in
Pernicious Anaemia Society
2 days ago
Upper left pain and soreness
Hi …. Does anyone else suffer from upper left quarter / centre pain and discomfort. Side almost feels sore (almost like muscular soreness). Constant belching and flatulence, sometimes loose or constipated. Been going on for 4 months. Had colonoscopy and Abdominal and Pelvic CT scan, all clear but symptoms
Hi …. Does anyone else suffer from upper left quarter / centre pain and discomfort. Side almost feels sore (almost like muscular soreness). Constant belching and flatulence, sometimes loose or constipated. Been going on for 4 months. Had colonoscopy and Abdominal and Pelvic CT scan, all clear but symptoms
Dh19
in
IBS Network
2 days ago
Confused about potential ibs c with overflow diagnosis
So after having a constant list of other symptoms unrelated to bowels i have finally spoke to a gastro who is assuming i have ibs c with overflow. I am on the waiting list for a colonoscopy so this potential diagnosis has been made on a 5 min phone call not an in person appointment. My confusion comes
So after having a constant list of other symptoms unrelated to bowels i have finally spoke to a gastro who is assuming i have ibs c with overflow. I am on the waiting list for a colonoscopy so this potential diagnosis has been made on a 5 min phone call not an in person appointment. My confusion comes
Confused1806
in
IBS Network
2 days ago
bowel blockage
Had bowel resection 6 years ago . Iliostomy bag and then successful reversal . Had an appendectomy about a year later, because my appendix were stuck to my ileostomy scar internally. I had pain and went to the hospital, but my surgery wasn’t emergency. I was scheduled about two weeks later for the appendectomy
Had bowel resection 6 years ago . Iliostomy bag and then successful reversal . Had an appendectomy about a year later, because my appendix were stuck to my ileostomy scar internally. I had pain and went to the hospital, but my surgery wasn’t emergency. I was scheduled about two weeks later for the appendectomy
Gardeningbuff
in
Bowel Disease Support
2 days ago
retroperitoneal mass
Hi,I have been diagnosed with deep infiltrative endometriosis and adenomyosis. On my MRI is also shows a sub rectal mass and a 8cm retroperitoneal mass. My ca125 blood tests have been between 72-94 but that could be caused by the endometriosis. I had a biopsy of the mass on thursday and anxiously waiting
Hi,I have been diagnosed with deep infiltrative endometriosis and adenomyosis. On my MRI is also shows a sub rectal mass and a 8cm retroperitoneal mass. My ca125 blood tests have been between 72-94 but that could be caused by the endometriosis. I had a biopsy of the mass on thursday and anxiously waiting
Eclair88
in
Endometriosis UK
3 days ago
little advice from fellow Coeliac’s
hi Was wondering if any other coeliac out there has had similar experience/symptons? I got diagnosed with Coeliac disease about 4 years ago I follow the diet, have separate toaster, chopping board etc I’ve been suffering with terrible upper tummy and back passage cramps, blood and yellow mucus
hi Was wondering if any other coeliac out there has had similar experience/symptons? I got diagnosed with Coeliac disease about 4 years ago I follow the diet, have separate toaster, chopping board etc I’ve been suffering with terrible upper tummy and back passage cramps, blood and yellow mucus
RJane83
in
Gluten Free Guerrillas
4 days ago
Advice on IBD
Hiya I was just wondering if other plp have experienced similar symptoms to me. I first became quite ill in dec last year where I woke up feeling sick, shaking and a lot of pain in my stomach. Went to hospital quite a few times in a lot of pain and they thought it was gastrorientis and then thought
Hiya I was just wondering if other plp have experienced similar symptoms to me. I first became quite ill in dec last year where I woke up feeling sick, shaking and a lot of pain in my stomach. Went to hospital quite a few times in a lot of pain and they thought it was gastrorientis and then thought
Buddybella
in
Crohn's and Colitis Support
4 days ago
labs results that contraindicate one another
Hi all, I’ve been having pretty constant parasthesias on both sides of my body usually worse from shoulders down to fingers, initial B12 level was 190 (was 845 four years ago). New doctor had me test for IF antibodies immediately after giving me a B12 injection which was negative and she stated
Hi all, I’ve been having pretty constant parasthesias on both sides of my body usually worse from shoulders down to fingers, initial B12 level was 190 (was 845 four years ago). New doctor had me test for IF antibodies immediately after giving me a B12 injection which was negative and she stated
Katep66875
in
Pernicious Anaemia Society
5 days ago
Pain on the right side near groin.
Hi there I have IBS D but for a while now I've been having pain in my lower right side near groin. It comes and goes and I have back ache on the lower right side. I had a colonoscopy 2 year ago all was ok just a polyp removed.Does anyone experience the same pain. Thank you 😊
Hi there I have IBS D but for a while now I've been having pain in my lower right side near groin. It comes and goes and I have back ache on the lower right side. I had a colonoscopy 2 year ago all was ok just a polyp removed.Does anyone experience the same pain. Thank you 😊
daydream1
in
IBS Network
5 days ago
Has anyone had stomach pain since being on Foster Nexthaler?
I'm having really bad stomach pain at night. My GP seems to think it an ulcer but 2 rounds of Lanzoprazole then Omeprazole have not helped. It's getting so I'm scared to eat and sleep. While I was up in the middle of the night last night, I suddenly thought that the onset of my stomach issues has coincided
I'm having really bad stomach pain at night. My GP seems to think it an ulcer but 2 rounds of Lanzoprazole then Omeprazole have not helped. It's getting so I'm scared to eat and sleep. While I was up in the middle of the night last night, I suddenly thought that the onset of my stomach issues has coincided
Kimmmmmmmmmmm
in
Asthma Community Forum
5 days ago
Rare diarrhoea
Would like to ask if switching from IBS c to IBS d is common. I’ve been trying to manage constipation for 40 years. I’m used to that.Yesterday’s urgency was really anxiety provoking for me. Thank you for reading.
Would like to ask if switching from IBS c to IBS d is common. I’ve been trying to manage constipation for 40 years. I’m used to that.Yesterday’s urgency was really anxiety provoking for me. Thank you for reading.
Sidney-dog
in
IBS Network
6 days ago
constipation leading to Pelvic Floor dysfunction
I have IBS - C and over the years the medical fraternity have prescribed laxatives for me. I’m following a low fermentation & FODMAP diet which works well for me. However my constipation due to a lot of straining has turned into PFD which basically means my anal muscles are out of sync. Does anyone suffer
I have IBS - C and over the years the medical fraternity have prescribed laxatives for me. I’m following a low fermentation & FODMAP diet which works well for me. However my constipation due to a lot of straining has turned into PFD which basically means my anal muscles are out of sync. Does anyone suffer
Profound15
in
IBS Network
7 days ago
thank you
thank you everyone for all the help you gave me recently, my husband is improving but will never be better like before, but any improvement is better than how he was. I too am feeling a little better, I did go to the hospital in the end, it seems I keep getting partial bowel obstruction and it eventually
thank you everyone for all the help you gave me recently, my husband is improving but will never be better like before, but any improvement is better than how he was. I too am feeling a little better, I did go to the hospital in the end, it seems I keep getting partial bowel obstruction and it eventually
2013mayo
in
PMRGCAuk
8 days ago
IBS-C pain at night
any suggestions? I either feel like I need to have several snacks before I can fall asleep at night (often because I’m so careful during the day that I sometimes undereat) OR I have severe bloating and constipation and pain that keeps me up for hours!
any suggestions? I either feel like I need to have several snacks before I can fall asleep at night (often because I’m so careful during the day that I sometimes undereat) OR I have severe bloating and constipation and pain that keeps me up for hours!
Hennen
in
IBS Network
8 days ago
side /back and stomach pain
Edit! Ok so I didn’t pick up the antibiotics Friday as it was 50% improved . It’s still not completely gone though. Maybe not even that!? If you were to stand with your hand on your left hip /waist with thumb at back ( you know !)that gap under rib hard to explain , that’s where it is and that part
Edit! Ok so I didn’t pick up the antibiotics Friday as it was 50% improved . It’s still not completely gone though. Maybe not even that!? If you were to stand with your hand on your left hip /waist with thumb at back ( you know !)that gap under rib hard to explain , that’s where it is and that part
Purplewoman
in
IBS Network
8 days ago
Gastritis
Hi all! Had my endoscopy last Friday.. my follow up (awaiting biopsies) I have mild erosive Gastritis which I understand can prevent B12 from absorbing? My Gastroenterologist says I haven’t got B12 deficiency ( before endoscopy) last test was 6 months ago! 226 ng/l (178ng/L - 2000ng/L (I did quote
Hi all! Had my endoscopy last Friday.. my follow up (awaiting biopsies) I have mild erosive Gastritis which I understand can prevent B12 from absorbing? My Gastroenterologist says I haven’t got B12 deficiency ( before endoscopy) last test was 6 months ago! 226 ng/l (178ng/L - 2000ng/L (I did quote
Doris11
in
Pernicious Anaemia Society
10 days ago
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