Reversing Intestinal Metaplasia ?

[Canadian77]

Good day friends. Came across this study and thought I would share and open conversation. Perhaps this can help us?

ncbi.nlm.nih.gov/pmc/articl...

[Myoldcat]

Very interesting! Thanks for sgmharing.

[Rexz]

Thank you Canadian77

This is an interesting study. Just a note that this study excluded those with AIG/PA. There are two types of Gastritis with intestinal metaplasia, one being Environmental Metaplastic Atrophic Gastritis (EMAG) and the other being Autoimmune Metaplastic Atrophic Gastritis (AMAG). EMAG being the very highly prevalent (~99%) of gastritis cases with AMAG at 1 to 1.5%. Hence most doctors know little about AMAG because they rarely see it.

The primary etiology (causation) of EMAG is H-Pylori bacterial infection. There are many studies where once the eradication, through antibiotics, of the H-Pylori is accomplished that its possible for gastritis to heal and some GIM reverses. However, for AMAG there is no known way to remove the chronic and continuous autoimmune insult to the oxyntic mucosa which is a prerequisite for the healing and subsequent GIM reversal to take place.

I might add that either EMAG or AMAG can result in B12 deficiency for completely different reasons. Also treatment for each differs so it's important to have a proper diagnosis.

Hope this is somewhat helpful.

Best wishes, Rexz

[boisland in reply to Rexz]

Rexz l There is a company in Austria working on a treatment for autoimmune gastritis. Here is the link on their 2020 press release. They are still not in clinal trials. marinomed.com/fileadmin/01_...

[Canadian77 in reply to boisland]

This is very nice to see. I wonder how long to get this to market

[Rexz in reply to boisland]

Thank you so much for this boisland

I've perused this and visited their site and is interesting. I'm not able to tell if this is a formulation of inflammatory reducing supplements, they do mention curcumin, an anti-inflammatory, or are they somehow treating the antibodies themselves that are ultimately causing the inflammation? There are treatments that I have taken such as immunosuppressant statins particularly Prednisone. However these are not a cure but rather a short term suppressant. There is another recent study regarding treatment with Mycophenolate Mofetil that in a single case study showed promise. However, I don't Believe either of these actually stop the autoimmune progressive destruction of the Parietal Cells which our bodies replace with intestinal metaplasia. All that said it's exciting that a private company is researching our AIG!! I have contacted them to learn more and will definitely share what I learn.

In the meantime, other than Curcumin, additional things to, I call it "tame" our inflammation that I do is eliminate inflammatory foods such as gluten, dairy, sugar, and snacks high in salt, I know, hard to do especially if you're a bread and cheese lover like me! I also take marshmallow root, you can take in capsule form or brewed as tea.

My gastritis is extensive Pangastritis, I've already had once instance of gastric cancer, so I've a keen interest in a cure for this. Thanks again for sharing.

Best wishes, Rexz

[Canadian77 in reply to Rexz]

Hey Rex. Where do you see them mention Curcumin?

I've taken this from time to time in past

[boisland in reply to Rexz]

Rexz - I was taking Low Dose Naltrexone (LDN) (very low does .25) and felt great, but on occasion flu like symptoms would kick in. They were present for a couple or more hours, then subside, but still very unpleasant. Stopped the LDN, the occasional symptoms stopped. I am going to try again as the LDN Trust Group seems to suggest when you encounter symptoms in the early days, you should try to give the LDN more time to see if symptoms subside. I never stayed on it for more than a month. I am hoping between the LDN and injections things will improve greatly for my stomach. It seems to work wonders for other autoimmune conditions regarding the suppressing of Hashi antibodies and ceasing of inflammation in other autoimmune conditions.

[Rexz in reply to boisland]

Boisland, hmmmm I had looked at LDN some time ago and shied away from it as the literature, although, said it helped autoimmune conditions stated it was immuno-enhancing? You know, I never get sick. Not a cold, runny nose, never the flue all my life...nothing. now I have Autoimmune Gastritis, Hashimoto's Thyroiditis, Sjogrens so I surmise my immune system is hyperactive. Therefore I've vectored towards immuno-suppressants.

There is progress being made in gene research to hopefully find the root cause of AIG.

Geez, you've now given me homework to go back and check out LDN!!! 🤣

Best wishes, Rex

[boisland in reply to Rexz]

Rexz What is LDN . This link takes you to other useful information. Many patients who have autoimmune disease tend to have low levels of endorphins, Met-enkephalin, aka opioid growth factor (OGF), an important "immunomodulatory". LDN modulates the immune system according to what has been shared on the LDN Research Trust - Low Dose Naltrexone group. I would take a second look at LDN. ldnresearchtrust.org/what-i...

[Canadian77 in reply to boisland]

What is LDN?

[boisland in reply to Canadian77]

Canadian77 I replied to Rexz w/ a link for What is LDN.

[boisland in reply to Rexz]

Rexz Someone just posted: ERR-gamma 'trains' stomach stem cells to become acid-producing cells in another AIG/PA group I belong to. She had emailed PhD in charge of the lab. Here is the link sciencedaily.com/releases/2...?

[Canadian77 in reply to boisland]

This is great. Thanks for posting. How do we get these ERR- Gamma lol

May I ask which group you are on that posted this?

[boisland in reply to Canadian77]

Canadian77 - Autoimmune Atrophic Gastritis & Pernicious Anemia is the FB group where the article was posted. The member who posted the article: ERR-gamma 'trains' stomach stem cells to become acid-producing cells has twin daughters who were diagnosed early in life with AIG. In my opinion there is nothing more powerful or anyone that will work harder than a mother trying to pursue a remedy or best possible treatment for their children. The other group I belong to was founded by a " mother " also attempting to get the best possible treatment for her child. She founded the Pernicious Anaemia/B12 Deficiency - Support Group.

[Canadian77 in reply to boisland]

Thank you, how old were her daughters? I am very fearful of passing this onto my kids also

[boisland in reply to Canadian77]

Canadian77 Lori Taylor who basically heads the FB group Autoimmune Atrophic Gastritis & Pernicious Anemia recently had a paper published: Creating a Framework for Treating Autoimmune Gastritis—The Case for Replacing Lost Acid. I share this link as it speaks to adding acid to replace the acid our parietal cells or lack of them cannot produce. The injections of B12 care for the lack of Intrinsic Factor , but what to do for lack of acid, the other function our parietal cells need to do. mdpi.com/2072-6643/16/5/662 . I would recommend you join both groups I mentioned .

[Rexz in reply to boisland]

This is excellent boisland

Thank you! Very interesting and although this is a long way off, unless you're a mouse of course, I find it so promising that new research in genetics is being done in the area of AIG and PA. Id love to have a Parietal Cells! My last Endo biopsies showed zero oxyntic mucosa. But on the positive side it's less weight to have to carry around. 😜

Thanks again for sharing this. Rexz

[boisland in reply to Rexz]

Rexz .. The member who sent an email to the lab Dr did get a response. Summarized: Unfortunately, they are a long way from treatment to bring back parietal cells in autoimmune gastritis. It will be a long time before they can use the approach in patients because the gene that stimulates parietal cells is also important for organs like the heart, so we would need to have a lot of safety data first! You knew this based on your initial response but wanted to share. Have a good evening !

[Canadian77 in reply to Rexz]

Hey Rexz, have you heard anything from Marionmed?

[Rexz]

In their website. Look at the "data" tab/page.

[Canadian77]

Has anyone seen this: ncbi.nlm.nih.gov/pmc/articl...

[Rexz in reply to Canadian77]

Yes, but again the etiology of the gastritis studied was H-Pylori infection. Once the infection is eradication e.g. the "insult" causing the gastritis it is then known that can be healed. With autoimmune gastritis the specific insult etiology is not yet known so it will always be a fight to heal... Think if it like a bonfire on one side someone is adding gasoline and the other side someone is adding water. The water may cool the fire somewhat but not put it out. Now think immunosuppressant where it's like someone kinking the gasoline hose slowing its application the cooling affect will be better and as I call it temper it tame the gastritis somewhat but will not heal.

Rexz

[Canadian77 in reply to Rexz]

This study specifically included those with Autoimmune and H.p infection. Seems like this amino acid helps both groups

researchgate.net/publicatio...

[Rexz in reply to Canadian77]

Hi Canadian, You're correct they mention CAG (Chronic Atrophic Gastritis) throughout the paper and yes, they have included “autoimmune gastritis” patients in the study however they never mention CAAG (Chronic Autoimmune Atrophic Gastritis). Either the study or the reporting of the study is flawed in that you should not combine the two CAG and CAAG in a study like this without including the results in the same fashion. There should be data other than aggregate percentages of improvement such as how many CAG only patients improved gastric function in the control group versus the study group and how many CAAG only patients showed improvement or not in the control versus the study group. The reason this is so important is that especially for a study like this you should not mix CAG and CAAG together since the insulting etiology on CAG as clearly stated has been removed for at least two years. However, the CAAG group, the autoimmune group, still has an ongoing insulting etiology (auto-antibodies to Parietal Cells).

This study is flawed in another way in that the title “Recovery of gastric function in patients affected by chronic atrophic gastritis using L-cysteine (Acetium®): one year survey in comparison with a control group” This title leads one to believe there was conclusive improvement? however there is weak evidence presented of any improvement as the conclusion states “…seems suggest a possible recovery in gastric function…" Again, the real data is not presented on how many of the participants in group 1 and 2 showed improvement but rather an aggregate percentage.

To be sure, this could be promising for people with CAAG. Clearly there is improvement of PGI and G17 serology on the combined (CAG and CAAG) group 1. On the other hand, quite possibly the 30 out of 77 patients in the control group with CAAG only may have experienced little to no improvement in PGI or G17 serology. We just don’t know.

Personally I would not use a single study report as evidence unless it is a meta-analysis of many research papers. I typically try and find research that is current, within the last 10 years preferably, which this one is, review the referenced research within that report, and then corroborate if possible with as many other studies and reports I can find. I also place some weight on the authors background as after you peruse many reports on a particular subject you will find who the experts are.

Hope this helps some, Rexz

[Canadian77 in reply to Rexz]

Thanks Rexz. Trying to hang onto any thread of hope

[Rexz in reply to Canadian77]

Yes! Don't lose hope. Just keep trying to tame your immune system. Also try and reduce stress.