Atopic and contact dermatitis - DNA tests

[mariiina]

Hello everyone.. Since I was a child a had some several skin problems, especialy atopic and contact dermatitis. One day it is better, another day it becomes unpleasant. I think I have tried everything to strenghten my immunity. Past few days I have discovered a possibility of a genetics DNA tests. As I understood these tests should find out what kind of problems with my skin I have and recommend me what to do. Does anyone of you has an experience with these tests? Did they help you? Thanks a lot for your advices..

[wobblybee Administrator Pioneer]

🤔 I found this info, it might be helpful. Ask your GP to refer you to a Dermatologist, rather than opting for ‘online testing’.

Allergic disorders tend to run in families; having a parent with atopic dermatitis, asthma, or hay fever raises the chances a person will develop atopic dermatitis.

When caused by CARD11 gene mutations, atopic dermatitis has an autosomal dominant inheritance pattern, which means one copy of the altered CARD11 gene in each cell is sufficient to cause the disorder.

Similarly, when associated with FLG gene mutations, risk of the condition follows an autosomal dominant pattern; a mutation in one copy of the FLG gene is sufficient to increase the risk of the disorder. Individuals with two altered copies of the FLG gene are more likely to develop the disorder and can have more severe signs and symptoms than individuals with a single altered copy.

When atopic dermatitis is associated with other genetic factors, the inheritance pattern is unclear. While CARD11 gene mutations appear to cause the condition without other contributing factors, people with changes in the FLG gene or another atopic dermatitis-associated gene inherit an increased risk of this condition, not the condition itself. Not all people with this condition have a mutation in a risk-associated gene, and not all people with a variation in a risk-associated gene will develop the disorder.

[DanaG214]

If you’re interested in doing the testing then go for it! It sounds like you’ve probably tried what dermatologist(s) recommend, and that hasn’t worked. So time to go a different route. Have you ever done any fungal or parasite testing?

[mariiina]

Hi ladies, thank you very much for your replies. I have tried many changes in my life already. Some of them were good, some of them not, but it is a life Anyway as Dana said, it is time to go a different route, for me.. for my kids in the future.. I have been looking for the tests, reading reviews and I found Chromozoom derma test. Seems to me like the most detailed in the market. I may give a try and let you know if I´ve got what I expected