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Coronary artery calcification, osteoporosis and B12 deficiency- what to do next ?

Cherylclaire profile image
CherylclaireForum Support
37 Replies

I have just been found to have coronary artery calcification incidentally when having a Lung Healthcare scan. This information was passed to my GP who wants to put me on statins (Atorvastatin 20mg daily). I have no idea of the severity or extent of the calcification, only that it was found. I don't think this scan even appears on my medical record.

I have asked that my D3/calcium tablets for osteoporosis of the spine be altered to D3 oil capsules. It does not seem sensible to take calcium any more, does it ?

I cannot find any advice about B12 deficiency: B12 injections and statins. Whether one would affect the other.

What to do next ? The booklets all talk about heart attacks and cholesterol, lipids, triglycerides and atherosclerosis - but no mention of calcification.

How can I find this information, so that I can make a decision regarding the statins ?

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Cherylclaire
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37 Replies
Leils profile image
Leils

K2 is an important one to take to direct the into the bones, not the arteries. Also important to have magnesium, if not already. I'd avoid statins at this stage, but obviously it's your call.

Best wishes x

Cherylclaire profile image
CherylclaireForum Support in reply to Leils

Yes. Already have been taking K2 alongside Evacal D3 tablets - also Raloxifene on prescription ("This medicine lowers total cholesterol and LDL ('bad') cholesterol. In general, it does not change triglycerides or HDL ('good') cholesterol." manufacturer's user information leaflet)

So difficult to make an informed opinion based on so little in the way of initial evidence- and a bombardment of rather ridiculous videos. Wonder where my scan is and how much detail it contains ?

Also worth knowing that, in the leaflet inside the Evacal D3 pack, under "warnings and precautions": "During long-term treatment the levels of calcium in your blood and urine and your kidney function have to be monitored regularly" !

Marz profile image
Marz in reply to Cherylclaire

amazon.co.uk/Vitamin-K2-Cal...

Happy to send you this book. If we only find one appropriate snippet of info - it has to be worth a read.... 🌻

Cherylclaire profile image
CherylclaireForum Support in reply to Marz

Have been taking K2 and Raloxifene. Both are supposed to help, and maybe they have, just not enough !

Think I need to start with an idea of what the scan actually shows. If I can find out, I'll let you know !

JanCymru profile image
JanCymru in reply to Marz

It's an excellent book - bought it several years ago when diagnosed with osteoporosis. Has lots of useful information. Well worth buying. x

Marz profile image
Marz in reply to JanCymru

Agree ! I think it was in the book that I read about calcium being involved in the breaking down of bone cells - osteoclasts. Osteoblasts are the cells involved in rebuilding bone ....Magnesium key too.

Parathyroids are involved in calcium levels - so maybe testing of PTH Levels could be helpful 🌻

Edit: @Cherylclaire

JanCymru profile image
JanCymru in reply to Marz

Yes, agree with your thoughts on testing of PTH levels too. Another great book is 'The Great Cholesterol Con' (the truth about what really causes heart disease and how to avoid it), by Dr Malcolm Kendrick. The main cause is stress and anxiety by the way! As if PA sufferers don't have enough stress already with trying to obtain a level of treatment to support their health!! Quite a hefty read but it tells you all about statins and their detrimental effect on health - the obvious ones but also it leads to muscle wastage which is the last thing you need when you are trying to maintain your balance when a bout of 'brain fog' hits! Again a very good read, dispelling the myths around cholesterol. The brain is dependant on cholesterol for health, so if you take statins to reduce cholesterol you are reducing the valuable cholesterol to support the brain - no wonder dementia is on the increase. A lot of information and well worth the read.

Marz profile image
Marz in reply to JanCymru

Yes a good read indeed. I met Dr Kendrick at a Thyroid UK conference and also at a B12 one at Loughborough Uni - both a few years ago. We had an interesting conversation about VitD and T3 over bteakfast !

Wwwdot profile image
Wwwdot

Hi Cherylclaire

Sorry to hear of this incidental finding. I think you are wise to learn more about the extent and scale of the calcification before you embark on what will be a commitment to that type of drug.

My husband has been on 20mg Atorvastatin for the last 5 years since he had a stent. I think from memory 20mg is the lowest dose and it appears to have steadied his condition ie at a recent check we were told his arteries were no worse and slightly improved.

I agree with you that the more facts you have to hand the better position to make an informed decision. You need to base that decision on your risks and benefits. Stopping the Atorvastatin is not an option for my husband as he has a stent so all we can do is try to stay on as low a dose as possible for as long as possible.

I am sure there are others on here with far more knowledge that I can offer.

🤗🤗🤗

Cherylclaire profile image
CherylclaireForum Support in reply to Wwwdot

Good to know - hearing others' experiences helps.

If I can track down the scan, I will have a baseline at least.

Sometimes, there aren't choices to be made, are there ? Lucky this was picked up, and lucky to have a choice right now. Good that this routine check picks up and reports back about other conditions, and hope that primary care able to cope with the influx of 'incidentals' !

Nackapan profile image
Nackapan in reply to Cherylclaire

Yes as this calcification was found on your lung function test by chance. It should be followed up by a Clear explanation and what it indeed means.

Otherwise they shouldn't have reported their findings with no follow up.

A repeat scan,?

Can the calcification clear ?

Has it caused cholesterol to rise ?

Is it a seperate problem?

Is it part of the criteria to prescribe statins ?

Have you been advised to stop calcium ?

Keep gathering as much information as possible.

Cherylclaire profile image
CherylclaireForum Support in reply to Nackapan

These are exactly the questions I have been trying to find answers for !

The scan: the letter, from "Lung Health Check Project Team", has no address/ contact details/ names, just tells me to take specific questions to GP.

The letter tells me that I have coronary artery calcification (CAC), and then gives general advice : that this condition "happens when calcium is deposited within the blood vessels (arteries) in the heart and can cause a narrowing of the arteries. This can also be made worse by smoking and is often related to high cholesterol and high blood pressure."

I haven't smoked for a decade, I don't have high blood pressure - and cholesterol was lowering but recently has gone up slightly, although has been higher previously.

I don't think the GPs have the scan. I did not see it when the GP found the letter on screen. She only has the same information that I have. How will my progress be monitored once on statins (if I decide to take them) ?

No, oddly I haven't been advised to stop taking calcium. That question was dismissed with "It's a different pathway" at my first appointment. So unclear what caused calcium build-up. Calcium levels in blood healthy.

The research that Technoid sent me, a 10-yr study of the effects of diet and supplement risk of CAC in older adults, finds that little from supplements is incorporated into bone but may contribute to ectopic calcification. The risk of CAC development, in those using supplements, was 22% higher than in those who did not supplement.

I now have a telephone appointment next week to discuss changing my tablets to oil-based D3 capsules. Have an awful feeling that this is with the "different pathway" doctor though ! This will be my third appointment and I'm none the wiser. Yet.

If no luck there, I can always write to my rheumatologist. She did once change my Risedronate to Raloxifene.

Nackapan profile image
Nackapan in reply to Cherylclaire

On your telephone consult ask if a cardiologist could answer your questions .Or where and who made the observation of the calcification .

And then a place with name to contact ?

So frustrating.

Write s list of questions.

Hope you can get more Information.

Cherylclaire profile image
CherylclaireForum Support in reply to Nackapan

Thanks, Nackapan - will prepare !

Nackapan profile image
Nackapan

I've just been reading b12 injections and statins can be taken together no contradictions being found .

Cherylclaire profile image
CherylclaireForum Support in reply to Nackapan

Well that's good news.

Delilahmy profile image
Delilahmy

Hi Cherylclaire… I find Ivor Cummings very knowledgeable on coronary artery calcification also his info on cholesterol and statins. I’ll post the link on YouTube and thoroughly recommend - he’s a great watch and also links evidence in his research …. Hope this helps

youtu.be/58RUfbqZCd8?si=BMM...

and this one which is more in depth view of cholesterol and atherosclerosis if anyone is interested xxx also Ivor Cummings

youtu.be/alZ47dgu3LU?si=0Wd...

Cherylclaire profile image
CherylclaireForum Support in reply to Delilahmy

I will watch these, thanks.

I have to say that I find watching these videos generally very difficult.

Technoid profile image
Technoid in reply to Cherylclaire

^ CherylClaire, the information I posted in your previous thread goes into all this in detail. I highly recommend you do NOT follow the advice from such as Ivor Cummings. These people are infamous in the nutrition science field for spreading dangerous nonsense.

Narwhal10 profile image
Narwhal10

I am sorry to read Cherylclaire, 😞

How are you feeling ? Both physically and was it an ugh situation ? What else do I have to live with ? 😫

You know your body better than anybody. You always have options. You can ‘trial’ something but only change ONE thing at a time.

My knowledge in this area is extremely poor. So, my line of thinking is along the lines of, using examples :-

1) See how you are not taking calcium for a week. By noting symptoms (use a diary).

2) Review situation. (Your body will tell you, listen to it. What do we know ? We are just random people on the internet).

3) Then once that is sorted, however, many weeks. Then consider the statin situation.

The physiological response is never to be underestimated. How an individual responds to something whether that food, alcohol, a medication, temperature, pain etc etc. 😘

Cherylclaire profile image
CherylclaireForum Support in reply to Narwhal10

How am I feeling ?

A bit surprised by this. Surprised that it never occurred to me that having calcium supplements might calcify me !

A bit scared by this. My mum and dad both had heart disease.

Physically, I feel no different.

I never knew that I had osteoporosis until I had a routine Dexascan - because I broke a couple of bones.

I would not have known that I had CAC unless this Lung Health Check scan had happened.

Now feel a little like I did when I first found out that I had B12 deficiency. (WHAT ???)

So much information to trawl through. No information offered regarding extent/severity of the calcification. Statins the go-to answer from primary care. But with little explanation offered as to what caused the calcification, how can statins help this particular condition ? And without access to the scan as a baseline, how will GPs know if they do ?

I find those videos difficult to watch. Would I pick up a book with that image on the cover ? Eg young man in a white coat , gurning puzzled face, scratching chin, giant red question-mark hovering above his tousled hair.

No. Makes my chalky heart sink.

Narwhal10 profile image
Narwhal10 in reply to Cherylclaire

Oh Cherylclaire,

I am so very sorry. Yes, of course, it can be daunting especially given parents. Sending a gentle hug.

It is tiring trying to learn about new conditions when managing so much already. Let your heart sink, have a cry or scream if needs be. Do something nice for yourself. Then another day slowly think about learning 20 minutes each day about what mischief your body is up to.

I too find videos difficult to watch.

Sending my best wishes.

Sleepybunny profile image
Sleepybunny

Hi,

I searched online for "arterial calcification statins" and found articles that said taking statins reduced risk of cardio-vascular events but increased rate of coronary artery calcification (CAC).

I hope you find the information you need to make your decisions.

Nackapan profile image
Nackapan in reply to Sleepybunny

How confusing 😕

Cherylclaire profile image
CherylclaireForum Support in reply to Sleepybunny

Heads or tails, Sleepybunny ?

Do you think that calcium is the result of previous fatty deposits, a change over time ? I wonder if this means that I have had this condition for a while then. Is it more stable than atherosclerosis ? This could explain the reduced risk of events. Less breaking away, less lesions caused, less blood clots formed ?

I think I'm stuck with the calcium I've accrued so far, but you can see why I'm not keen to add to that with the supplements for osteoporosis (which did decrease to osteopenia after all - and who knew that could happen ?) The oil-based capsules of D3 without the calcium seems like a fair ask in this position.

Thanks for looking. So much info, a lot of conflict. GPs in general seem very keen on statins, and can't understand why patients so reluctant.

The advice from the Lung Health project team who scanned me was to look on British Heart Foundation website - so will let you know if I find out anything useful there.

Narwhal10 profile image
Narwhal10 in reply to Sleepybunny

Thanks Sleepybunny,

It is like a see-saw. Getting the right balance of things. We are all so different and no, not more homework. A frazzled brain which is tired and foggy. A person has to have a shower, dress, cook, feed self and trying to run an orderly, tidy home is beyond me. So, I just do very basic. 😳

Technoid profile image
Technoid in reply to Sleepybunny

Yes, thats correct Sleepybunny, statins calcify the existing soft plaque which stabilizes it, reducing risks of plaque rupture. This is why statins "freeze" risk but cannot really eliminate risk as the existing plaque is not actually removed but stabilized.

Cherylclaire profile image
CherylclaireForum Support in reply to Technoid

So to decide whether prescribed statins are working well , it would be a good idea to be able to monitor effectiveness - only possible by first knowing extent and severity of the existing calcification.

How to either get past primary care to find out by being scanned again or finding the original scan where calcification was evident is proving problematic. Why the first scan could not have been sent with the letter to the surgery in the beginning, I'm not sure.

Once again, after treatment has started, this opportunity is lost.

Marz profile image
Marz

The NHS website does mention getting the thyroid in order before taking a statin ... Have your calcium levels been tested ?

Cherylclaire profile image
CherylclaireForum Support in reply to Marz

Under "Bone profile" : serum calcium 2.42 mmol/L (no range given)

Under "Thyroid Function test" : serum free T4 level 12.3 pmol/L (range 11.00 - 21.20 pmol/L) and serum TSH level 1.84 mlU/L (range 0.27 - 4.20 mlU/L).

[These were results from blood tests done on 19th October.]

Marz profile image
Marz in reply to Cherylclaire

Your thyroid is producing a very low level of the hormone T4. This is a storage hormone and needs to convert into the Active T3 - which was not tested - and yet the most important test. Every cell in your body has a receptor for T3 and it is Low T3 that can be the cause of many symptoms - including raised cholesterol. As your Free T4 is very low then it follows FT3 will also be low.

With your FT4 being so low you would normally see a much higher TSH - stimulating the thyroid to produce more of the hormone T4. Central Hypothyroidism should be considered - think we have discussed this before - where the Pituitary gland is a problem....and the TSH - FT4 - FT3 are all low in range. Maybe take a look back at earlier thyroid results....

Cherylclaire profile image
CherylclaireForum Support in reply to Marz

May be time to have another full test .

Have two sisters with Grave's disease, so some thyroid issues in family history.

Marz profile image
Marz in reply to Cherylclaire

That certainly should be considered when putting together your medical jigsaw ....

I wonder how your sisters were diagnosed with Graves ? Hopefully with the correct anti-bodies being tested. Hashimotos - which can lead to being HYPO - in the early stages - can lead to Graves type symptoms - HYPER. Yes it's a minefield....

Cherylclaire profile image
CherylclaireForum Support in reply to Marz

Not sure - but both have had Grave's for a long time now. Also common in family history vitiligo and psoriasis.

Yes, a minefield, Marz.

Technoid profile image
Technoid

I found this extract, hope it may be useful.

"There are two recognized types of coronary artery calcification: atherosclerotic and medial artery calcification. Atherosclerotic calcification chiefly occurs in the intima [2], when inflammatory mediators and elevated lipid content within atherosclerotic lesions induce osteogenic differentiation of vascular smooth muscle cells [3]. Conversely, coronary artery calcification in the media is associated with advanced age, diabetes, and chronic kidney disease [4]. Both calcification types contribute to arterial stiffness, which increases the risk for adverse cardiovascular events in the general population, decreases the rate of revascularization success, and increases the likelihood of procedural complications."

from "Intravascular lithotripsy: plaque modification in preparation for stenting"

in Debulking in Cardiovascular Interventions and Revascularization Strategies, Shmuel Chen, Giora Weisz, 2022

sciencedirect.com/topics/me...

Cherylclaire profile image
CherylclaireForum Support in reply to Technoid

Thanks, Technoid - it well might be. A specific cause always helps understanding- even if the resultant complications are the same.

[Let's hope no reason to prep for stents !]

Technoid profile image
Technoid in reply to Cherylclaire

Yes indeed!

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