Growing experimental evidence strongly places mitochondrial dysfunction as a prominent feature in PD, making it a possible therapeutic target. With no available therapies and the substantial evidence supporting Nrf2 signalling in mitochondrial homeostasis and integrity, targeting the Keap1-Nrf2 pathway provides an exciting therapeutic strategy for PD. A large volume of research indicates that Nrf2 plays a significant role in the maintenance of mitochondrial health, including the mitochondrial membrane potential, respiration, mitophagy and mitochondrial biogenesis. Whether these functions are all met by Nrf2 in the PD brain remains to be further explored. However, promising preclinical evidence already shows the protective effect of pharmacological Nrf2 activation in models of PD. Further unravelling of the underlying mechanisms by which Nrf2 contributes to the maintenance of mitochondrial homeostasis in PD may lead to promising new therapies.
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Hello! Very interesting informatiob and website. Thank you! Could you tell me how to make the tea? / where to find it? Do I start from (organic) seeds and follow a certain procedure? 🙏
Melatonin is a potent Nrf2 activator and also is a potent maintainer of effective mitochondrial function. In people with PD, it helped maintain mitochondrial homeostasis and reduced oxidative stress levels to healthy control levels which are both problems in people with PD. Melatonin is produced directly in mitochondria so it can rapidly apply these positive protective effects. Unfortunately, melatonin levels decline with age and even more so in PwP. Melatonin replacement therapy has proven beneficial in people with PD.
There are three popular human studies using melatonin in people with PD , one at 10 mg and two at 50 mg and all three showed positive effects. Here are links to those studies :
What brand do you recommend (will check availability in Ireland and UK)?
I read in some places that Melatonin should be used for the short term only and also not if one has an autoimmune diseases (link below). Though PD is not classified as an autoimmune disease (AID), but with parkinson's leading to many other other symptoms which share borderline with AID, I'm just wondering based on your research, what's your opinion on this? Many thanks
That is a generality based on the idea that melatonin may improve the immune response, but many autoimmune diseases are likely associated with a dysbiotic gut. FMT can work against many autoimmune diseases by improving a dysbiotic gut microbiome. Melatonin is one component that naturally works to improve the dysbiotic gut. I have an autoimmune disease and take a lot of melatonin without a problem.
I use dissolve in the mouth tablets to try to improve bioavailability.
I have not seen any literature that validates the idea of short term use of melatonin.
Well, it is not easy to measure nrf2 activation but my best guess is that if you notice stabilisation or improvement that you are on the right track. It takes time... lets put it this way: you start with an inflammation status at -100. When you start nrf2 activation (through all means possible) you have to get to 0. And then go beyond to the + side. Then you can/might/will feel getting better. A whole physiological cascade starts when nrf2 does its job : glutathion production increases, idem for catalase, for SOD, etc.... all these intracellulaer processes increase health. It is never "one thing" that does the trick. Using one nrf2 supplement and not caring about food, omegas, astaxanthine, vit E, cold showers, fasting,... is not the way to go.
Thank you so much for your post. I think I need to do more research myself, bcos I don't know a lot on this subject. But parkinson's has beaten the strength out of me. No longer the person I used to be years ago
Hey SAGoodman , even though you can't sprout, you could try freeze dried broccoli sprouts: KOYAH - Organic USA Broccoli Sprout Powder (1 Scoop = 1/4 Cup Sprouts): 36 Servings, Freeze-Dried, Tested for Active Myrosinase and Glucoraphanin (Sulforaphane Glucosinolate), Great in Smoothies amazon.com/gp/product/B082Z...
For example, low inflammatory diets and exercise were associated with high Nrf2 activity and are appropriate for practically everyone (Pall 2015). Incorporating foods that contain curcumin (from turmeric), sulfurophane (broccoli), vitamin D, and Omega 3s all show Nrf2 benefits." also quercetin
I take a Nrf2 synergizer called Protandim from Life Vantage, ( a multi-level company - I just purchase product.) It's formulated from extracts of milk thistle, bacopa, ashwaganda, curcumin, and green tea - one caplet/day. I believe it is helpful although I can't say specifically how. I've been taking it for almost 5 years. If I stopped it for a month I could assess it's impact better, but I might feel worse, and who wants that!! ;-D
Hi! I know about this product and it claims. Been considering it for a while. Do you feel like it slows your PD down? Or did it reverse symptoms? Do you combine it with specific diet and other supplements? (Like omega 3, Vit D, astaxanthine,...).
I also supplement a half dose of a multi-vit/min, 1 gram Vit C, and 500 mg glutathione plus 1 t. mannitol and 1/2 t (I think 1000mg) of lion's mane mushroom extract powder plus sporadic D3. I've been vegan for~40 years. I walk 5,000 steps a day (2+ miles), weight train 2x/week and am implementing a core routine.
I was diagnosed 10 years ago with primary symptom, slowness. I'm Non-Tremor Dominant - only a slight occasional tremor but now significant stiffness and balance issues. No prescription meds. I manage okay and prefer to know my many NMS are PD and not med. side effects. (and the see-saw of on/off would be very hard on me emotionally.)
So, 5 years of Protandim...can't give you definite reversals, but you have a better overall picture of my protocol. I believe I'm progressing slowly. I don't drive but I do all the housework, cook the meals, do laundry, track our finances, and live in Thailand where my husband serves as a missionary, (my "work" is to manage my lifestyle and stress so we can stay here as long as possible!)
I've been without medication since my diagnosis in December 2020. Fortunately, things are looking very promising for me at the moment. I'm very active.... parkinsonclub.de
Any PwP who suffers from non motor symptoms - fatigue, urinary urgency/nocturia, drooling, depression, weak voice, poor sleep quality etc must try broccoli seed tea from resolveparkinsons.org
Others have mentioned taking broccoli sprouts. Broccoli seeds have orders of magnitude more sulfurathane besides Dr Albert Wright has devised a method of optimising the output by brewing with a plant based enzyme. The resultant remedy has enabled me sleep through the night or go on a 4 hour car journey without needing the bathroom.
IMHO broccoli seed tea is the single most important PD remedy - ever! If a remedy is also found that has a similar impact on motor symptoms, then PD will become very easy to live with.
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