I have history of multiple miscarriages , this was my 7th egg retrieval and now the age is over 37.My PGT test report confirm
2-low level mosaicism and rest aneuploid.
Please help if any one have had success with low level mosaicism.
I have history of multiple miscarriages , this was my 7th egg retrieval and now the age is over 37.My PGT test report confirm
2-low level mosaicism and rest aneuploid.
Please help if any one have had success with low level mosaicism.
Following.
We also have 2 low mosaics, a history of implantation failure and miscarriage. We and are having a meeting with a Genetic Counsellor on Monday so hope to understand more as my consultant doesn’t seem keen to transfer the 2 low mosaic due to higher chance of miscarriage.
Has your embryologist explained what a low-level mosaic embryo means? That might help put your mind at ease. Hope you get some replies from this forum as all the ladies very supportive towards each other
Take care
Janet
We have two low mosaics, but haven't yet had them transferred, so cannot unfortunately give you a success story. We have had genetic counselling, however and, as i understand it, the risks attached to low mosaics, depend on: (i) the particular chromosomes affected, and (ii) the number.
I would suggest you discuss with a genetic counsellor.
Yes.. will visit this Saturday
Don't lose hope. Based on the advice we received from our genetic counsellor, we will probably give one of the low mosaics ago . I did a fair amount of research, and there are lots of success stories with low mosaic embryos (there are even success stories with abnormal embryos - there are countries e.g. the US where you can have an abnormal embryo transferred).
I've had success with low-level mosaic and abnormal. Key seems to be if it will implant; if so most likely the embryo is fine. I have twins from a low-level + abnormal transfer (amnio was all clear on both) and currently 7.5wk (confirmed HB) with low-level mosaic (will take some weeks before amnio to know outcome, but so far they are confident). The "genetic counselor" HIGHLY recommended I NOT transfer any of these. I received different advice from an RE that specializes in this area (embryo genetics) who advised that 3/4 embryos I had tested were "good" to try with. His view was all low-level mosaics should be viewed as "fine" as if they implant they are highly likely to be perfect (no fetal anomalies have been reported from continuing pregnancies with low-level mosaics). Try with any abnormals where abnormalities would not permit embryonic development if accurate (i.e. not use embryos with concerning trisomies).Hope this helps! Good luck
Side note: While I see a role for PGA-T for women with multiple implantation failure or recurrent miscarriage for fetal anomalies - personal view is going down the PGT-A route caused me more psychological harm than good. I had blasts that were not good enough for testing discarded and months of total distress when I received the results and my then RE told me it was time to discard these and go to donor eggs. I am glad I sought more specialized advice.
Here are some articles that may help:
Y.X. Zhang, J.J. Chen, S. Nabu, Q.S.Y. Yeung, Y. Li, J.H. Tan, et al.
The pregnancy outcome of mosaic embryo transfer: a prospective multicenter study and meta-analysis
Genes, 11 (2020), p. 973
Nathan R. Treff, Diego Marin,
The mosaic embryo: misconceptions and misinterpretations in preimplantation genetic testing for aneuploidy,
Fertility and Sterility,
Volume 116, Issue 5,
2021,
Pages 1205-1211
scholar.google.com/scholar_...
there’s a Facebook group called my perfect mosaic u should check out all the success stories there
my understanding is that mosaicism exists when a blastocyst contains more than one cell line. One is euploid/normal, and the other has a chromosomal aberration. In low mosaicism the aberration is minimal and not considered incompatible with life. Some babies are born with their bodies made of two cell lines, and are otherwise healthy. And some blastos/fetuses have one cell line overwhelm the other - in other words the normal cell line can overwhelm and overtake the aberrant cell line so that your baby is born made of only one euploid/normal cell line. Here in America most reproductive endocrinologists are happy to transfer low-mosaic blastos. It seems there is a tendency for them to sort themselves out. The research is optimistic. Good luck!